Products Instruments Hyperion XTi Imaging System

Hyperion XTi Imaging System   

Hyperion XTi Imaging System   

Unlocking New Views in Spatial Biology    

Introducing new groundbreaking capabilities for multiplexed tissue imaging at never-before-seen speeds and automation. The Hyperion XTi™ Imaging System is now available with three imaging modes for rapid and detailed analysis and automated slide loading for walk-away automation.


Discover the throughput and precision that is revolutionizing spatial biology.
See the new features
Hyperion XTi Imaging System   

See the next generation in spatial biology

High-throughput multiplexed whole slide tissue maging: Hyperion™ XTi now offers the ability to automate slide loading for continuous acquisition and new whole slide imaging modes for rapid and detailed analysis. 

Visualize tissue heterogeneity in 20 minutes.

 
 
 
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Take a deep dive into translational and clinical applications that explore new views of cellular composition within the tissue microenvironment.

View imaging modes applied

TECHNOLOGY

Powered by proven Imaging Mass Cytometry™ (IMC™) technology, Hyperion XTi is a multiplexed tissue imager that uses metal-tagged antibodies, instead of fluorophores, to simultaneously and reliably acquire 40-plus protein and RNA markers, without autofluorescence interference. IMC is the trusted choice for researchers and continues to be featured in high-impact publications – making it the most reliable tool for highly multiplexed imaging.

 

See data quickly.


Researchers can visualize 40-plus markers in real time, without managing time-consuming acquisition cycles – expediting the time to deeper analysis.

 
 
 
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Represents Hyperion XTi Preview Mode for a large tissue section over 25 minutes. Researchers can select and view from any markers on the panel during acquisition.

See data clearly.


Clearly define areas in any tissue type ― including lung, bone marrow, colon and brain ― without background autofluorescence and spectral overlap.

In bone marrow, cyclic immunofluorescence data (right) shows false positives, highlighted by co-localization of B cells (CD20+) and T cells (CD3+) (yellow). Conversely, distinct B cells (green) and T cells (red) can be seen with IMC (left).

Discover the power of Imaging Mass Cytometry


Image any tissue type with no autofluorescence interference

Co-detection of protein and RNA on the same tissue

Automated slide loader for walk-away acquisition

Three acquisition modes to accommodate any type of research

Batch staining workflow for high-volume studies

Multimodal capabilities with imaging and flow cytometry capabilities

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Hartland Jackson, PHD

Entering an era of new biology with rapid, high-throughput imaging

Faster means more samples, more data. We can push through more of these small samples or we can do whole slides on the Hyperion XTi

Hartland Jackson, PhD
Investigator
Lunenfeld-Tanenbaum Research Institute, Sinai Health

WORKFLOW

40 slides. 40-plus markers. 24 hours.

Load up to 40 slides and walk away.

Incorporate a new level of throughput and efficiency with the Hyperion XTi Slide Loader. The optional slide loader enables automatic loading and acquisition of up to 40 slides. It is equipped with a barcoded slide reader for easy sample identification, providing researchers with peace of mind when managing precious tissue samples.

See more from your samples.
Do more with your time.

Preview Mode | Number of markers: 42, Acquisition time: 20 minutes, Sample: colon cancer (25 mm x 15 mm)
Preview Mode | Number of markers: 42, Acquisition time: 20 minutes, Sample: colon cancer (25 mm x 15 mm)
Cell Mode | Number of markers: 42, Acquisition time: 2 hours, Sample: colon cancer (2 mm x 2 mm), Resolution: 1 μm
Cell Mode | Number of markers: 42, Acquisition time: 2 hours, Sample: colon cancer (2 mm x 2 mm), Resolution: 1 μm
Tissue Mode | Number of markers: 42, Acquisition time: 5 hours and 50 minutes, Sample: breast cancer (24 mm x 16 mm, Resolution: 5 μm
Tissue Mode | Number of markers: 42, Acquisition time: 5 hours and 50 minutes, Sample: breast cancer (24 mm x 16 mm, Resolution: 5 μm

Multiplexed imaging – without compromising speed


An end-to-end workflow to get results faster

A workflow to get results faster

A one-step staining and detection workflow


Imaging Mass Cytometry enables 40-plus markers that can be simultaneously stained, acquired and visualized. Other fluorescence-based approaches involve iterative rounds of staining, imaging and removal of fluorescent signals. The IMC workflow is without sequential immunostaining approaches, multiple slide treatment rounds or acquisition steps.

Protein and RNA co-detection


Detect protein and RNA on the same tissue sample to correlate transcriptional signatures and the spatial context of pathogens, host cells or protein sources. Explore this multi-omic workflow that combines RNAscope™ technology with IMC to visualize key RNA and protein markers in the same samples.

 

This image highlights RNA and protein co-detection in lung squamous cell carcinoma using the Hyperion XTi Imaging System and a 33-marker panel combined from three ready-to-go reagent kits.

Need to ship or store slides?


  • All-at-once batch staining of all slides to reduce technical variation
  • Acquire at any time from shipped and/or stored slides that have been stained
  • Analyze previously banked tissue slides to be correlated to known clinical outcomes
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Let us do the work for you.

Did you know Standard BioTools™ has an in-house service lab? Send us your samples and we will send you the data.