Genomics in clinical and translational research
Scalable, high-throughput gene expression with the Biomark X9 System
Integrating genomic insights into drug development enhances the ability to identify biomarkers, validate drug targets and understand treatment response. The Biomark™ X9 System for High-Throughput Genomics empowers researchers to scale gene expression analysis with speed, precision and efficiency across the full drug development pipeline.
Interested in biomarker discovery?
Read this publication digest to see the Biomark X9 System in action.
Genomics in clinical and translational research
Scalable, high-throughput gene expression with the Biomark™ X9 System
Integrating genomic insights into drug development enhances the ability to identify biomarkers, validate drug targets and understand treatment response. The Biomark X9 System for High-Throughput Genomics empowers researchers to scale gene expression analysis with speed, precision and efficiency across the full drug development pipeline.
Interested in biomarker discovery?
Read this publication digest to see Biomark X9 in action
Where scalable gene expression analysis delivers values
A growing number of initiatives require expanding genomic applications to match larger-scale clinical and translational research studies. The ability to scale analysis enables the generation of larger and more comprehensive genetic profiles – covering multiple therapeutic areas such as immunology, oncology, neuroscience and metabolic disorders.
Basic research and early drug discovery
Study disease biology and molecular pathways
Identify and prioritize novel therapeutic targets
Preclinical research
Track dose- and time-dependent gene expression changes
Understand drug mechanism, efficacy and toxicity in models
Translational research
Validate biomarkers of safety, efficacy or disease across large cohorts
Stratify patients with confidence for clinical studies
With a unique technology that easily supports analysis at scale, Biomark systems empower effective discovery and development, revealing the context and interactions between drugs, diseases, treatments and genes.
Key challenges in drug development gene expression studies
Low sample throughput limits study scale
Traditional platforms are slow and costly for large multi-timepoint or dose-response studies.
Limited sample availability
Scarce clinical or preclinical samples demand low-input, high-sensitivity solutions.
High cost and complex workflows
Sequencing methods require expensive reagents, infrastructure and long analysis times.
Long turnaround delays decisions
Slow workflows limit rapid assessment of drug response and patient stratification.
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Accelerate drug development with the Biomark X9 System
High-throughput genomic profiling, with flexibility and precision
The Biomark X9 System simplifies and scales gene expression analysis for clinical and translational research. Built on microfluidic technology, it delivers rapid, high-content data with unmatched efficiency, ideal for fast-paced drug development environments.
Comprehensive profiling with gold-standard qPCR
- Profile 10–192 targets per run for deep insight into disease biology, target modulation and biomarker response
- Choose your genes of interest using TaqMan or other hydrolysis probe-based assays – no need for complex re-optimization
High efficiency at scale
- Run up to 9,216 singleplex reactions per run using nanoliter volumes, saving precious samples and reducing reagent costs
- Designed for high-throughput studies without compromising data quality or increasing workflow complexity
Fast, automated workflow
- Get gene expression or genotyping results in approximately four hours with minimal hands-on time. Compact, walk-away automation supports reproducible results with consistent performance across studies.
Biomark systems use microfluidic chips to generate 100x more data in one run than traditional plate-based real-time PCR workflows, accelerating the detection of relevant disease associations.
This offers unparalleled efficiency in drug development and capabilities to carry potential targets through safety and efficacy testing and validation with confidence.
Biomark systems combine the benefits of
high multiplexing with the ease of singleplex reactions
Click to see a platform comparison
Biomark platforms provide the advantages of multiplexing without the inefficiencies and complexity of having to manage mixed primer pairs and probes. This is accomplished using microfluidics-based chips, in which thousands of miniaturized individual reactions run in parallel, saving sample volume, assay development time and issues with fluorescent channel overlap. While many platforms offer either high multiplexing features at the cost of complex workflows or simplicity at the cost of scale, Biomark systems offer efficiency, high content generation and ease of use, ideal for fast-paced clinical research settings.
* Using 1,000 samples by 96 assays (get more information about these calculations)
Achieve gold-standard data quality and precision
in a faster, fully automated workflow
Integrated fluidic circuits (IFCs) form the backbone of the Biomark X9 System, supporting different configurations of samples and assays for simultaneous profiling of multiple types of genomic assay readouts. Each Dynamic Array™ IFC is precision-manufactured to exacting standards of performance and reliability.
Supporting clinical and translational deployment with consistent, high-quality output
With the ability to generate genotyping and gene expression results in approximately four hours, Biomark systems significantly quicken decision-making throughout clinical and translational research phases compared with traditional RNA-seq methods. This fast and consistent data generation supports go/no-go decisions early in the clinical development process, reducing risks and costs associated with late-stage failures.
The Biomark X9 System ensures high-throughput data generation alongside data reliability and quality, which is crucial for drug discovery and development pipelines. A wide dynamic range and linear amplification provides higher confidence in results through better analytical performance, ensuring reproducible amplification across 96 samples at once
Case studies
Resources
Biomarker Discovery and Target Validation
Exploring Diagnostic and Prognostic Biomarkers for Targeted Therapy
High-Throughput Genomics for Every Stage of Drug Development
D3 genomic services
Improve study designs and optimize results using D3™ Assay Design service. Access the latest in genomic analysis – including pharmacogenomic analysis, respiratory pathogen detection, and biomarker discovery and validation – for every project and from any sample type.
Meet the Biomark X9 system
The Biomark X9 System empowers faster and better genotyping and gene expression workflows than conventional systems, simultaneously detecting up to 96 targets against 96 samples with an automated singleplex approach. Using only nanoliter-scale reactions reduces consumable costs and minimizes waste for a cost advantage without compromising data quality.
Capitalize on operational efficiency with an automated workflow that minimizes hands-on time, leading to lower labor costs and faster project turnaround.
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